Hlaváč Jan Ph.D.

Hlaváč Jan Ph.D.'s picture

Publications (Impact Factor Journals):

  • [46]
    OKOROCHENKOVA, Y., M. PORUBSKÝ, S. BENICKÁ a J. HLAVÁČ. A novel three-fluorophore system as a ratiometric sensor for multiple protease detection. Chemical Communications. 2018, 54(55), 7589-7592. ISSN 1359-7345. IF: 6.319. PMID: 29796477
  • [45]
    BÜRGLOVÁ, K., G. RYLOVÁ, A. MARKOS, H. PŘICHYSTALOVÁ, M. SOURAL, M. PETRÁČEK, M. MEDVEDÍKOVÁ, G. TEJRAL, B. SOPKO, P. HRADIL, P. DŽUBÁK, M. HAJDÚCH a J. HLAVÁČ. Identification of Eukaryotic Translation Elongation Factor 1-α 1 Gamendazole-Binding Site for Binding of 3-Hydroxy-4(1 H)-quinolinones as Novel Ligands with Anticancer Activity. Journal of Medicinal Chemistry. 2018, 61(7), 3027-3036. ISSN 0022-2623. IF: 6.259. PMID: 29498519
  • [44]
    FUNK, P., K. MOTYKA, M. SOURAL, M. MALOŇ, H. KOSHINO, J. KUSZ a J. HLAVÁČ. Study of 2-aminoquinolin-4(1H)-one under Mannich and retro-Mannich reaction. PLOS One. 2017, 12(5), e0175364. ISSN 1932-6203. IF: 3.057. PMID: 28557987
  • [43]
    VOLNÁ, T., K. MOTYKA a J. HLAVÁČ. RP-HPLC determination of dissociation constant using solely aqueous mobile phase. Journal of Pharmaceutical and Biomedical Analysis. 2017, 134, 143-148. ISSN 0731-7085 . IF: 3.169. PMID: 27915191
  • [42]
    KŘUPKOVÁ, S., G. AQUETE, L. KOCMANOVÁ, T. VOLNÁ, M. GREPL, L. NOVAKOVA, M. MILLER a J. HLAVÁČ. Solid-Phase Synthesis of ɤ-Lactone and 1,2-Oxazine Derivatives and Their Efficient Chiral Analysis. PLOS One. 2016, 11(11), e0166558. ISSN 1932-6203 . IF: 2.806. PMID: 27893812
  • [41]
    BRULÍKOVÁ, L., A. HARRISON, M. MILLER a J. HLAVÁČ. Stereo- and regioselectivity of the hetero-Diels-Alder reaction of nitroso derivatives with conjugated dienes. Beilstein Journal of Organic Chemistry. 2016, 12, 1949-1980. ISSN 1860-5397 . IF: 2.337. PMID: 27829901
  • [40]
    BRULÍKOVÁ, L., Y. OKOROCHENKOVA a J. HLAVÁČ. A solid-phase synthetic approach to pH-independent rhodamine-type fluorophores. Organic and Biomolecular Chemistry. 2016, 14(44), 10437-10443. ISSN 1477-0520. IF: 3.564. PMID: 27754510
  • [39]
    BÜRGLOVÁ, K., S. OKOROCHENKOV a J. HLAVÁČ. Efficient Route to Deuterated Aromatics by the Deamination of Anilines. Organic Letters. 2016, 18(14), 3342-3345. ISSN 1523-7060. IF: 6.579. PMID: 27378277
  • [38]
    KUBOVIČOVÁ, L., K. BÜRGLOVÁ a J. HLAVÁČ. New (green) methodology for efficient hydrazine cleavage. Organic and Biomolecular Chemistry. 2016, 14(21), 4824-4828. ISSN 1477-0520 . IF: 3.564. PMID: 27143442
  • [37]
    JEDINÁKOVÁ, P., P. SEBEJ, T. SLANINA, P. KLAN a J. HLAVÁČ. Study and application of noncatalyzed photoinduced conjugation of azides and cycloocta-1,2,3-selenadiazoles. Chemical Communications. 2016, 52(26), 4792-4795. ISSN 1359-7345. IF: 6.319. PMID: 26956058
  • [36]
    SCHADICH, E., J. HLAVÁČ, T. VOLNÁ, L. VARANASI, M. HAJDÚCH a P. DŽUBÁK. Effects of Ginger Phenylpropanoids and Quercetin on Nrf2-ARE Pathway in Human BJ Fibroblasts and HaCaT Keratinocytes. BioMed Research International . 2016, 2016, 2016:2173275. ISSN 2314-6133. IF: 2.476. PMID: 26942188
  • [35]
    PERLÍKOVÁ, P., G. RYLOVÁ, P. NAUŠ, T. ELBERT, E. TLOUŠŤOVÁ, A. BOURDERIOUX, L. SLAVĚTÍNSKÁ, K. MOTYKA, D. DOLEŽAL, P. ZNOJEK, A. NOVÁ, M. HARVANOVÁ, P. DŽUBÁK, M. ŠILLER, J. HLAVÁČ, M. HAJDÚCH a M. HOCEK. 7-(2-Thienyl)-7-deazaadenosine (AB61), a new potent nucleoside cytostatic with a complex mode of action. Molecular Cancer Therapeutics. 2016, 15(5), 922-937. ISSN 1535-7163 . IF: 5.764. PMID: 26819331
  • [34]
    SMYSLOVÁ, P., I. POPA, A. LYČKA, G. TEJRAL a J. HLAVÁČ. Non-Catalyzed Click Reactions of ADIBO Derivatives with 5-Methyluridine Azides and Conformational Study of the Resulting Triazoles. PLOS One. 2015, 10(12), e0144613 . ISSN 1932-6203. IF: 3.057. PMID: 26673606
  • [33]
    OKOROCHENKOV, S., K. BÜRGLOVÁ, I. POPA a J. HLAVÁČ. Solid-Supported Hydrazone of 4-(4 '-Formyl-3 '-methoxyphenoxy)butyric Acid As a New Traceless Linker for Solid-Phase Synthesis. Organic Letters. 2015, 17(2), 180-183. ISSN 1523-7060. IF: 6.732. PMID: 25536078
  • [32]
    RYLOVÁ, G., T. OŽDIAN, L. VARANASI, M. SOURAL, J. HLAVÁČ, D. HOLUB, P. DŽUBÁK a M. HAJDÚCH. Affinity-Based Methods in Drug-Target Discovery. Current Drug Targets. 2015, 16(1), 60-76. ISSN 1389-4501. IF: 3.029. PMID: 25410410
  • [31]
    MOTYKA, K., J. STYSKALA, P. CANKAR a J. HLAVÁČ. Fluorescence Properties of Selected Benzo[c]phenanthridines. Fluorescence. 2014, 24(4), 1177-1182. ISSN 1053-0509. IF: 1.927. PMID: 24796969
  • [30]
    KŘUPKOVÁ, S., P. FUNK, M. SOURAL a J. HLAVÁČ. 4‑Chloro-2-Fluoro-5-Nitrobenzoic Acid as a Possible Building Block for Solid-phase Synthesis of Various Heterocyclic Scaffolds. ACS Combinatorial Science. 2013, 15(1), 20-28. ISSN 2156-8952. IF: 3.636. PMID: 23163899
  • [29]
    BRULÍKOVÁ, L., J. HLAVÁČ a P. HRADIL. DNA interstrand cross-linking agents and their chemotherapeutic potential. Current Medicinal Chemistry. 2012, 19(3), 364-385. ISSN 0929-8673. IF: 4.070. PMID: 22335513
  • [28]
    BRULÍKOVÁ, L., P. DŽUBÁK, M. HAJDÚCH a J. HLAVÁČ. Synthesis of Various 5-Alkoxymethyluracil Analogues and Structure-Cytotoxic Activity Relationship Study. Carbohydrate Research. 2011, 346(14), 2136-2144. ISSN 0008-6215. IF: 2.332. PMID: 21864833
  • [27]
    MOTYKA, K., J. HLAVÁČ, B. VAŇKOVÁ, M. SOURAL a P. FUNK. Purine Scaffold Effect on Fluorescence Properties of Purine-Hydroxyquinolinone Bisheterocycles. Journal of Fluorescence. 2011, 21(6), 2207-2212. ISSN 1053-0509. IF: 2.107. PMID: 21826428
  • [26]
    BRULÍKOVÁ, L. a J. HLAVÁČ. Synthesis, reactivity and biological activity of 5-alkoxymethyluracil analogues. Organic Chemistry. 2011, 7(80), 678-698. ISSN 1860-5397. IF: 2.517. PMID: 21804865
  • [25]
    VAŇKOVÁ, B., V. KRCHŇÁK, M. SOURAL a J. HLAVÁČ. Direct C-H Arylation of Purine on Solid Phase and Its Use for Chemical Libraries Synthesis. ACS Combinatorial Science. 2011, 13(5), 496-500. ISSN 2156-8952. IF: 3.450. PMID: 21675766
  • [24]
    SOURAL, M., J. HLAVÁČ, P. FUNK, P. DŽUBÁK a M. HAJDÚCH. 2-Phenylsubstituted-3-Hydroxyquinolin-4(1H)-one-Carboxamides: Structure-Cytotoxic Activity Relationship Study. ACS Combinatorial Science. 2011, 13(1), 39-44. ISSN 1520-4766. IF: 3.450. PMID: 21247123
  • [23]
    VAŇKOVÁ, B., J. HLAVÁČ a M. SOURAL. Solid-Phase Synthesis of Highly Diverse Purine-Hydroxyquinolinone Bisheterocycles. Journal of Combinatorial Chemistry. 2010, 12(6), 890-894. ISSN 1520-4766. IF: 3.125. PMID: 20849113
  • [22]
    HRADIL, P., J. HLAVÁČ, M. SOURAL, M. HAJDÚCH, M. KOLÁŘ a R. VEČEŘOVÁ. 3-Hydroxy-2-phenyl-4(1H)-quinolinones as Promising Biologically Active Compounds. Mini-reviews in Medicinal Chemistry. 2009, 9(6), 696-702. ISSN 1389-5575. IF: 3.132. PMID: 19519495
  • [21]
    SPÁČILOVÁ, L., P. DŽUBÁK, M. HAJDÚCH, S. KŘUPKOVÁ, P. HRADIL a J. HLAVÁČ. Synthesis and cytotoxic activity of various 5-[alkoxy-(4-nitro-phenyl]-methyl]-uracils in their racemic form. Biorganic & Medicinal Chemistry Letters. 2007, 17(23), 6647-6650. ISSN 0960-894X. IF: 2.538. PMID: 17935983
  • [20]
    SOURAL, M., J. HLAVÁČ, P. HRADIL, I. FRYŠOVÁ, M. HAJDÚCH, V. BERTOLASI a M. MALOŇ. Synthesis and Cytotoxic Activity of Substituted 2-Phenyl-3-Hydroxy-4(1H)-Quinolinones-7- Carboxylic Acids and their Phenacyl Esters. European Journal of Medicinal Chemistry. 2006, 41(4), 467-474. ISSN 0223-5234. IF: 2.022. PMID: 16540209
  • [19]
    STYSKALA, J., J. HLAVÁČ a P. CANKAR. Synthesis of oxidative dihydroxy metabolites of benzo(c) phenanthridines. Tetrahedron. 2013, 69(23), 4670-4678. ISSN 0040-4020. IF: 2.817.
  • [18]
    SOURAL, M., P. HRADIL, S. KŘUPKOVÁ a J. HLAVÁČ. An Interesting Synthetic Pathway to Some Quinolin-4(1H)ones: Phenacylanthranilates Rearrangement – Limits and Scopes. Mini-Reviews in Organic Chemistry. 2012, 9(4), 426-432. ISSN 1570-193X/1875-6298. IF: 1.063.
  • [17]
    CANKAŘOVÁ, N., P. FUNK, J. HLAVÁČ a M. SOURAL. Novel preloaded resins for solid-phase biotinylation of carboxylic acids. Tetrahedron Letters. 2011, 52(44), 5782-5788. ISSN 0040-4039. IF: 2.683.
  • [16]
    MOTYKA, K., J. HLAVÁČ, M. SOURAL, P. HRADIL, P. KREJČÍ, L. KVAPIL a M. WEISS. Fluorescence properties of some 2-(4-aminosubstituted-3-nitrophenyl)-3-hydroxyquinolin-4(1H)-ones. Tetrahedron Letters. 2011, 52(6), 715-717. ISSN 0040-4039. IF: 2.683.
  • [15]
    SOURAL, M., P. FUNK, L. KVAPIL, P. HRADIL, J. HLAVÁČ a V. BERTOLASI. Study of anthranilate cyclisation to 2-hydroxymethyl-2,3-dihydroquinazolin-4(1H)-ones and an alternative synthetic route. Archive for Organic Chemistry. 2010, 10(-), 255-265. ISSN 1551-7004. IF: 1.096.
  • [14]
    MOTYKA, K., J. HLAVÁČ, M. SOURAL a P. FUNK. Fluorescence properties of 2-aryl-3-hydroxyquinolin-4(1H)-one-carboxamides. Tetrahedron Letters. 2010, 38(51), 5060-5063. ISSN 0040-4039. IF: 2.618.
  • [13]
    HARRISON, A., M. MELCHIONNA, P. FRANCO a J. HLAVÁČ. Solid-phase synthesis and analysis of 3,6-dihydro-2H-1,2-oxazines in their stereo- and regio isomer mixtures. New Journal of Chemistry. 2014, 38(11), 5491-5499. ISSN 1144-0546. IF: 3.086.
  • [12]
    BÜRGLOVÁ, K., J. HLAVÁČ a J. BARTLETT. Synthesis of sol-gel silica particles in reverse micelles with mixed-solvent polar cores: tailoring nanoreactor structure and properties. Journal of Nanoparticle research. 2015, 17(7), 308-308. ISSN 1388-0764. IF: 2.101.
  • [11]
    BUZGO, M., J. GREPLOVA, M. SOURAL, D. BEZDEKOVA, A. MIČKOVÁ, O. KOFRONOVA, O. BENADA, J. HLAVÁČ a E. AMLER. PVA immunonanofibers with controlled decay. Polymer. 2015, 77(-), 387-398. ISSN 0032-3861. IF: 3.586.
  • [10]
    BÜRGLOVÁ, K., J. HLAVÁČ a J. BARTLETT. Synthesis of silica nanoparticles for encapsulation of oncology drugs with low water solubility: effect of processing parameters on structural evolution. Journal of Nanoparticle Research. 2015, 17(12), -. ISSN 1388-0764. IF: 2.101.
  • [9]
    BRULÍKOVÁ, L., S. KŘUPKOVÁ, M. LABORA, K. MOTYKA, L. HRADILOVÁ, M. MISTRÍK, J. BÁRTEK a J. HLAVÁČ. Synthesis and study of novel pH-independent fluorescent mitochondrial labels based on Rhodamine B. RSC Advances. 2016, 6(28), 23242-23251. ISSN 2046-2069 . IF: 3.108.
  • [8]
    VOLNÁ, T., K. MOTYKA a J. HLAVÁČ. Potential of High Performance Liquid Chromatography for Distribution Coefficient Determination of 3 Hydroxyquinolin 4(1H) one Derivatives. Chromatographia. 2016, 79(17), 1153-1163. ISSN 0009-5893. IF: 1.402.
  • [7]
    KRÁTKÁ, L. a J. HLAVÁČ. impakt zatim neni_clanek je v recenzovanych_Study of Enantioselective Catalysis of Nitroso-Diels-Alder Reaction on Solid Support. Chemistryselect. 2017, 2(14), 3987-3992. ISSN 2365-6549. IF: x.
  • [6]
    OKOROCHENKOVA, Y. a J. HLAVÁČ. Novel ratiometric xanthene-based probes for protease detection. Dyes and Pigments. 2017, 143, 232-238. ISSN 0143-7208. IF: 3.473.
  • [5]
    SOURAL, M., J. HLAVÁČ, P. HRADIL a M. HAJDÚCH. Efficient Synthesis and Cytotoxic Activity of Some Symmetrical Disulfides Derived from the Quinolin-4(1H)-one Skeleton. European Journal of Organic Chemistry. 2009, -(23), 3867-3870. ISSN 1434-193X. IF: 3.016.
  • [4]
    BÜRGLOVÁ, K., S. OKOROCHENKOV, M. BUDESINKY a J. HLAVÁČ. Efficient Method for Aromatic-Aldehyde Oxidation by Cleavage of Their Hydrazones Catalysed by Trimethylsilanolate. European Journal of Organic Chemistry. 2017, 2017(2), 389–396. ISSN 1099-0690. IF: 2.834.
  • [3]
    PETRÁČEK, M., L. BRULÍKOVÁ, K. MOTYKA a J. HLAVÁČ. From Study of Catalytic Hydrogenation to Novel Ratiometric pH Indicators with Quinoline Scaffold. ChemistrySelect. 2017, 2(24), 7325-7331. ISSN 2365-6549. IF: NA.
  • [2]
    MEJDROVA, I., L. BRULÍKOVÁ, T. VOLNÁ a J. HLAVÁČ. Regioselective synthesis of 5-[(2,3-dihydroxypropoxy)methyl]uracil analogues. New Journal of Chemistry. 2017, 41(20), 12178-12189. ISSN 1144-0546. IF: 3.269.
  • [1]
    BÜRGLOVÁ, K. a J. HLAVÁČ. Application of Trimethylsilanolate Alkali Salts in Organic Synthesis. Synthesis-Stuttgart. 2018, 50(6), 1199-1208. ISSN 0039-7881. IF: 2.65.

Publications (Other Reviewed Journals):

  • [1]
    KRÁTKÁ, L. a J. HLAVÁČ. Study of Enantioselective Catalysis of Nitroso-Diels-Alder Reaction on Solid Support. Chemistryselect. 2017, 2(14), 3987-3992. ISSN 2365-6549.

Patents, Utility models & other IP's :

[7] TRACELESS HYDRAZINE LINKERS FOR SOLID PHASE SYNTHESIS, Appl. PV 2014-640
  1. Patent: CZ 306 100, Granted: 22. 6. 2016, Ownership: Palacky University Olomouc, Inventors: Hlaváč Jan, Okorochenkov Sergei, Bürglová Kristýna

Status: Available

[6] FLUORESCENT DERIVATIVE FOR NON-CATALYTIC LABELING OF NUCLEIC ACID AND PEPTIDE COMPONENTS, PUV 2016-32558
  1. Utility Model: CZ 30 136, Granted: 13. 12. 2016, Ownership: Palacky University, Olomouc, Inventors: Jedináková Petra, Hlaváč JanVáclavková Jana, Konečný Petr, Džubák Petr, Hajdúch Marián

Status: Available

[5] FLUORESCENT PROBE OF RHODAMIDE-FLUORESCEIN TYPE FOR pH DETERMINATION, PUV 2016-32557
  1. Utility Model: CZ 30 104, Granted: 6. 12. 2016, Ownership: Palacky University Olomouc, Inventors: Okorochenkova Yana, Hlaváč Jan, Motyka Kamil

Status: Available

[4] 2-PHENYL-3-HYDROXYQUINOLIN-4(1H)-ONE-8-CARBOXAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND USE, Priority Appl. CZ PV 2010-476
  1. Patent: CZ 304 527, Granted: 7. 5. 2014, Ownership: Palacky University Olomouc, Inventors: Soural Miroslav, Hlaváč Jan, Hradil Pavel

Status: Terminated

[3] EFFICIENT METHOD OF BIOTINYLATION OF AMINO COMPOUNDS USING SOLID PHASE SYNTHESIS FOR AFFINITY CHROMATOGRAPHY NEEDS, Priority Appl. CZ PV 2010-229
  1. Patent: CZ 302 669, Granted: 13. 7. 2011, Ownership: Palacky University in Olomouc, Inventors: Soural MiroslavHlaváč JanHradil Pavel

Status: Terminated

[2] EFFICIENT METHOD OF BIOTINYLATION OF COMPOUNDS CONTAINING CARBOXYL GROUP USING SOLID PHASE SYNTHESIS FOR AFFINITY CHROMATOGRAPHY NEEDS, Priority Appl. CZ PV 2010-230
  1. Patent: CZ 302 510, Granted: 11. 5. 2011, Ownership: Palacky University Olomouc, Inventors:Soural Miroslav, Hlaváč Jan, Hradil Pavel

Status: Terminated

[1] DERIVATES OF 2-PHENYL-3-HYDROXYQUINOLINE-4(1H)-ONE AND METHODS OF THEIR PREPARATION AND UTILIZATION, Priority Appl. CZ PV 2006-546
  1. Patent: CZ 300 589, Granted: 13. 5. 2009, Ownership: Palacky University Olomouc, Inventors: Krejčí Petr, Hlaváč Jan, Hradil Pavel, Hajdúch Marián
  2. Patent: US 8,299,092, Granted: 30. 10. 2012, Ownership: Palacky University Olomouc, Inventors: Krejčí Petr, Hlaváč Jan, Hradil Pavel, Hajdúch Marián
  3. Patent: EP 2 064 200, Granted: 4. 9. 2013, Ownership: Palacky University Olomouc, Inventors: Krejčí Petr, Hlaváč Jan, Hradil Pavel, Hajdúch Marián

Status: Terminated


Doctoral students mentor:

[5] Zuzana Barbuščáková, Molecular system for multiple detection of enzymes inside the cell,
Ph.D. specialization: , status: Ongoing, from: 2018
[4] Leona Krátká, Stereoselective synthesis on solid support,
Ph.D. specialization: Organic chemistry, status: Ongoing, from: 2015
[3] Martin Porubský, Preparation and study of new fluorescent systems for intracellular imaging,
Ph.D. specialization: , status: Ongoing, from: 2015
[2] Leona Kocmanová, Stereoselective synthesis on solid support ,
Ph.D. specialization: , status: Ongoing, from: 2015
[1] Petra Jedináková, Preparation of compounds for copper free click reactions,
Ph.D. specialization: , status: Ongoing, from: 2013


Master students mentor:

[2] Leona Kocmanová, Synthesis of Oxazine Derivatives on Solid Support,
status: Graduated, from: 2013 to 2015
[1] Ivana Spurná, Study catalyzed and nekatalyzovaných Click reaction with selected 5'-azido nucleosides,
status: Graduated, from: 2013 to 2014