Soural Miroslav Ph.D.

Soural Miroslav Ph.D.'s picture
Phone: +420 585634418
Curriculum Vitae: download

Publications (Impact Factor Journals):

  • [47]
    KRÁLOVÁ, P., V. RUČILOVÁ a M. SOURAL. Polymer-Supported Syntheses of Heterocycles Bearing Oxazine and Thiazine Scaffolds. ACS Combinatorial Science. 2018, -, -. ISSN 2156-8952. IF: 3.500. PMID: 30040392
  • [46]
    KRÁLOVÁ, P. a M. SOURAL. Synthesis of 2-Alkylsulfonyl-imidazoles with Three Diversity Positions from Immobilized α-Acylamino Ketones. ACS Combinatorial Science. 2018, 20(8), 467-471. ISSN 2156-8952. IF: 3.500. PMID: 29969011
  • [45]
    KRÁLOVÁ, P., M. MALOŇ, H. KOSHINO a M. SOURAL. Convenient Synthesis of Thiohydantoins, Imidazole-2-thiones and Imidazo[2,1-b]thiazol-4-iums from Polymer-Supported α-Acylamino Ketones. Molecules. 2018, 23(4), pii: E976. ISSN 1420-3049. IF: 2.861. PMID: 29690582
  • [44]
    BÜRGLOVÁ, K., G. RYLOVÁ, A. MARKOS, H. PŘICHYSTALOVÁ, M. SOURAL, M. PETRÁČEK, M. MEDVEDÍKOVÁ, G. TEJRAL, B. SOPKO, P. HRADIL, P. DŽUBÁK, M. HAJDÚCH a J. HLAVÁČ. Identification of Eukaryotic Translation Elongation Factor 1-α 1 Gamendazole-Binding Site for Binding of 3-Hydroxy-4(1 H)-quinolinones as Novel Ligands with Anticancer Activity. Journal of Medicinal Chemistry. 2018, 61(7), 3027-3036. ISSN 0022-2623. IF: 6.259. PMID: 29498519
  • [43]
    KRAJČOVIČOVÁ, S., J. STANKOVÁ, P. DŽUBÁK, M. HAJDÚCH, M. SOURAL a M. URBAN. A Synthetic Approach for the Rapid Preparation of BODIPY Conjugates and their use in Imaging of Cellular Drug Uptake and Distribution. Chemistry- A European Journal. 2018, 24(19), 4957-4966. ISSN 0947-6539. IF: 5.317. PMID: 29411907
  • [42]
    VANDA, D., M. SOURAL, V. CANALE, S. CHAUMONT-DUBEL, G. SATALA, T. KOS, P. FUNK, V. RUČILOVÁ, B. LEMROVÁ, K. P., E. PEKALA, A. BOJARSKI, P. POPIK, P. MARIN a P. ZAJDEL. Novel non-sulfonamide 5-HT6 receptor partial inverse agonist in a group of imidazo[4,5-b]pyridines with cognition enhancing properties. European Journal of Medicinal Chemistry. 2017, 144(2018), 716-729. ISSN 0223-5234. IF: 4.519. PMID: 29291439
  • [41]
    KRAJČOVIČOVÁ, S., T. GUCKÝ, D. HENDRYCHOVA, V. KRYŠTOF a M. SOURAL. A Stepwise Approach for the Synthesis of Folic Acid Conjugates with Protein Kinase Inhibitors. Journal of Organic Chemistry. 2017, 82(24), 13530-13541. ISSN 0022-3263. IF: 4.849. PMID: 29171753
  • [40]
    KRÁLOVÁ, P., M. MALOŇ a M. SOURAL. Stereoselective Synthesis of Benzo[e][1,4]oxazino[4,3-a][1,4]diazepine-6,12-diones with Two Diversity Positions. ACS Combinatorial Science. 2017, -, -. ISSN 2156-8952. IF: 3.168. PMID: 29048877
  • [39]
    KRÁLOVÁ, P., M. MALOŇ, T. VOLNÁ, V. RUČILOVÁ a M. SOURAL. Polymer-Supported Stereoselective Synthesis of Benzoxazino[4,3-b][1,2,5]thiadiazepinone 6,6-dioxides. ACS Combinatorial Science. 2017, 19(10), 670-674. ISSN 2156-8952. IF: 3.168. PMID: 28825802
  • [38]
    FUNK, P., K. MOTYKA, M. SOURAL, M. MALOŇ, H. KOSHINO, J. KUSZ a J. HLAVÁČ. Study of 2-aminoquinolin-4(1H)-one under Mannich and retro-Mannich reaction. PLOS One. 2017, 12(5), e0175364. ISSN 1932-6203. IF: 3.057. PMID: 28557987
  • [37]
    KRÁLOVÁ, P., V. FÜLÖPOVÁ, M. MALOŇ, T. VOLNÁ, I. POPA a M. SOURAL. Stereoselective Polymer-Supported Synthesis of Morpholine- and Thiomorpholine-3-carboxylic Acid Derivatives. ACS Combinatorial Science. 2017, 19(3), 173-180. ISSN 2156-8952 . IF: 3.317. PMID: 28085245
  • [36]
    KRAJČOVIČOVÁ, S. a M. SOURAL. Solid-phase synthetic strategies for the preparation of purine derivatives. ACS Combinatorial Science. 2016, x, x. ISSN 2156-8952 . IF: 3.168. PMID: 27248804
  • [35]
    TRAPANI, P., T. VOLNÁ a M. SOURAL. Solid-Phase Synthesis of 2,3-Dihydrobenzo[f][1,2,5]thiadiazepin-4(5H)-one 1,1-Dioxides with Three Diversity Positions. ACS Combinatorial Science. 2016, 18(6), 349-354. ISSN 2156-8952 . IF: 3.168. PMID: 27163513
  • [34]
    SOURAL, M., J. HODOŇ, N.J. DICKINSON, V. ŠIDOVÁ, S. GURSKÁ, P. DŽUBÁK, M. HAJDÚCH, J. ŠAREK a M. URBAN. Preparation of Conjugates of Cytotoxic Lupane Triterpenes with Biotin. Bioconjugate Chemistry. 2015, 26(12), 2563-70. ISSN 1043-1802. IF: 4.818. PMID: 26537839
  • [33]
    FÜLÖPOVÁ, V. a M. SOURAL. Mining the Chemical Space: Application of 2/4-Nitrobenzenesulfonamides in Solid-Phase Synthesis. ACS Combinatorial Science. 2015, 17(10), 570-591. ISSN 2156-8952. IF: 3.317. PMID: 26325251
  • [32]
    VANDA, D., R. JORDA, B. LEMROVÁ, T. VOLNÁ, V. KRYŠTOF, C. MCMASTER a M. SOURAL. Synthesis of Novel N9‑Substituted Purine Derivatives from Polymer Supported α‑Amino Acids. ACS Combinatorial Science. 2015, 17(7), 426-432. ISSN 2156-8952. IF: 3.317. PMID: 26098936
  • [31]
    RYLOVÁ, G., T. OŽDIAN, L. VARANASI, M. SOURAL, J. HLAVÁČ, D. HOLUB, P. DŽUBÁK a M. HAJDÚCH. Affinity-Based Methods in Drug-Target Discovery. Current Drug Targets. 2015, 16(1), 60-76. ISSN 1389-4501. IF: 3.029. PMID: 25410410
  • [30]
    FROMMEL, J., M. ŠEBELA, G. DEMO, R. LENOBEL, T. POSPÍŠIL, M. SOURAL a D. KOPECNY. N‑acyl‑ω‑aminoaldehydes are efficient substrates of plant aminoaldehyde dehydrogenases. Amino Acids. 2015, 47(-), 175-187. ISSN 0939-4451. IF: 3.196. PMID: 25344796
  • [29]
    LEMROVÁ, B., P. SMYSLOVÁ, I. POPA, T. OŽDIAN, P. ZAJDEL a M. SOURAL. Directed Solid-Phase Synthesis of Trisubstituted Imidazo[4,5-c]pyridines and Imidazo[4,5-b]pyridines. ACS Combinatorial Science. 2014, 16(10), 558-565. ISSN 2156-8952. IF: 3.032. PMID: 25046560
  • [28]
    HARTMANOVÁ, L., P. FRYČÁK, M. SOURAL, F. TUREČEK, V. HAVLÍČEK a K. LEMR. Ion internal energy, salt tolerance and a new technical improvement of desorption nanoelectrospray. Journal of Mass Spectrometry. 2014, 49(8), 750-754. ISSN 1076-5174. IF: 2.379. PMID: 25044903
  • [27]
    MCMASTER, C., V. FÜLÖPOVÁ, I. POPA, M. GREPL a M. SOURAL. Solid-Phase Synthesis of Anagrelide Sulfonyl Analogues. ACS Combinatorial Science. 2014, 16(5), 221-224. ISSN 2156-8952. IF: 3.032. PMID: 24725158
  • [26]
    MESSINA, I., I. POPA, V. MAIER a M. SOURAL. Solid-Phase Synthesis of 5-Noranagrelide Derivatives. ACS Combinatorial Science. 2014, 16(1), 33-38. ISSN 2156-8952. IF: 3.032. PMID: 24304422
  • [25]
    KŘUPKOVÁ, S., P. FUNK, M. SOURAL a J. HLAVÁČ. 4‑Chloro-2-Fluoro-5-Nitrobenzoic Acid as a Possible Building Block for Solid-phase Synthesis of Various Heterocyclic Scaffolds. ACS Combinatorial Science. 2013, 15(1), 20-28. ISSN 2156-8952. IF: 3.636. PMID: 23163899
  • [24]
    FÜLÖPOVÁ, V., T. GUCKÝ, M. GREPL a M. SOURAL. Solid-Phase Synthesis of Trisubstituted Benzo[1,4]-Diazepin-5-one Derivatives. ACS Combinatorial Science. 2012, 14(12), 651-656. ISSN 2156-8952. IF: 3.636. PMID: 23145965
  • [23]
    LEMROVÁ, B. a M. SOURAL. Solid-Phase Synthesis of 4,7,8-Trisubstituted 1,2,3,4-Tetrahydro-benzo[e][1,4]diazepin-5-ones. ACS Combinatorial Science. 2012, 14(12), 645-650. ISSN 2156-8952. IF: 3.636. PMID: 23121176
  • [22]
    MOTYKA, K., J. HLAVÁČ, B. VAŇKOVÁ, M. SOURAL a P. FUNK. Purine Scaffold Effect on Fluorescence Properties of Purine-Hydroxyquinolinone Bisheterocycles. Journal of Fluorescence. 2011, 21(6), 2207-2212. ISSN 1053-0509. IF: 2.107. PMID: 21826428
  • [21]
    VAŇKOVÁ, B., V. KRCHŇÁK, M. SOURAL a J. HLAVÁČ. Direct C-H Arylation of Purine on Solid Phase and Its Use for Chemical Libraries Synthesis. ACS Combinatorial Science. 2011, 13(5), 496-500. ISSN 2156-8952. IF: 3.450. PMID: 21675766
  • [20]
    SOURAL, M., J. HLAVÁČ, P. FUNK, P. DŽUBÁK a M. HAJDÚCH. 2-Phenylsubstituted-3-Hydroxyquinolin-4(1H)-one-Carboxamides: Structure-Cytotoxic Activity Relationship Study. ACS Combinatorial Science. 2011, 13(1), 39-44. ISSN 1520-4766. IF: 3.450. PMID: 21247123
  • [19]
    VAŇKOVÁ, B., J. HLAVÁČ a M. SOURAL. Solid-Phase Synthesis of Highly Diverse Purine-Hydroxyquinolinone Bisheterocycles. Journal of Combinatorial Chemistry. 2010, 12(6), 890-894. ISSN 1520-4766. IF: 3.125. PMID: 20849113
  • [18]
    HRADIL, P., J. HLAVÁČ, M. SOURAL, M. HAJDÚCH, M. KOLÁŘ a R. VEČEŘOVÁ. 3-Hydroxy-2-phenyl-4(1H)-quinolinones as Promising Biologically Active Compounds. Mini-reviews in Medicinal Chemistry. 2009, 9(6), 696-702. ISSN 1389-5575. IF: 3.132. PMID: 19519495
  • [17]
    SOURAL, M., J. HLAVÁČ, P. HRADIL, I. FRYŠOVÁ, M. HAJDÚCH, V. BERTOLASI a M. MALOŇ. Synthesis and Cytotoxic Activity of Substituted 2-Phenyl-3-Hydroxy-4(1H)-Quinolinones-7- Carboxylic Acids and their Phenacyl Esters. European Journal of Medicinal Chemistry. 2006, 41(4), 467-474. ISSN 0223-5234. IF: 2.022. PMID: 16540209
  • [16]
    KADRIĆ, J., K. MOTYKA, P. DŽUBÁK, M. HAJDÚCH a M. SOURAL. Synthesis, cytotoxic activity, and fluorescence properties of a set of novel 3-hydroxyquinolin-4(1H)-ones. Tetrahedron Letters. 2014, 55(26), 3592-3595. ISSN 0040-4039. IF: 2.379.
  • [15]
    SOURAL, M., P. HRADIL, S. KŘUPKOVÁ a J. HLAVÁČ. An Interesting Synthetic Pathway to Some Quinolin-4(1H)ones: Phenacylanthranilates Rearrangement – Limits and Scopes. Mini-Reviews in Organic Chemistry. 2012, 9(4), 426-432. ISSN 1570-193X/1875-6298. IF: 1.063.
  • [14]
    CANKAŘOVÁ, N., P. FUNK, J. HLAVÁČ a M. SOURAL. Novel preloaded resins for solid-phase biotinylation of carboxylic acids. Tetrahedron Letters. 2011, 52(44), 5782-5788. ISSN 0040-4039. IF: 2.683.
  • [13]
    MOTYKA, K., J. HLAVÁČ, M. SOURAL, P. HRADIL, P. KREJČÍ, L. KVAPIL a M. WEISS. Fluorescence properties of some 2-(4-aminosubstituted-3-nitrophenyl)-3-hydroxyquinolin-4(1H)-ones. Tetrahedron Letters. 2011, 52(6), 715-717. ISSN 0040-4039. IF: 2.683.
  • [12]
    SOURAL, M., P. FUNK, L. KVAPIL, P. HRADIL, J. HLAVÁČ a V. BERTOLASI. Study of anthranilate cyclisation to 2-hydroxymethyl-2,3-dihydroquinazolin-4(1H)-ones and an alternative synthetic route. Archive for Organic Chemistry. 2010, 10(-), 255-265. ISSN 1551-7004. IF: 1.096.
  • [11]
    MOTYKA, K., J. HLAVÁČ, M. SOURAL a P. FUNK. Fluorescence properties of 2-aryl-3-hydroxyquinolin-4(1H)-one-carboxamides. Tetrahedron Letters. 2010, 38(51), 5060-5063. ISSN 0040-4039. IF: 2.618.
  • [10]
    LEMROVÁ, B. a M. SOURAL. Synthetic strategies for preparing bicyclic guanidines. European Journal of Organic Chemistry. 2015, 2015(-), 1869-1886. ISSN 1434-193X. IF: 3.068.
  • [9]
    FUNK, P., K. MOTYKA, P. DŽUBÁK, P. ZNOJEK, S. GURSKÁ, J. KUSZ, C. MCMASTER, M. HAJDÚCH a M. SOURAL. Preparation of 2-phenyl-3-hydroxyquinoline- 4(1H)-one-5-carboxamides as potential anticancer and fluorescence agents. RSC Advances. 2015, 5(60), 48861-48867. ISSN 2046-2069. IF: 3.289.
  • [8]
    FÜLÖPOVÁ, V., P. FUNK, I. POPA, C. MCMASTER a M. SOURAL. Solid-Phase Synthesis of Trisubstituted Benzo[f][1,2,3]triazolo[1,5-a][1,4]- diazepin-6(5H)-ones and Their Sulfonyl Analogues under Mild Reaction Conditions. European Journal of Organic Chemistry. 2015, 16(-), 3551-3557. ISSN 1434-193X. IF: 3.068.
  • [7]
    BUZGO, M., J. GREPLOVA, M. SOURAL, D. BEZDEKOVA, A. MIČKOVÁ, O. KOFRONOVA, O. BENADA, J. HLAVÁČ a E. AMLER. PVA immunonanofibers with controlled decay. Polymer. 2015, 77(-), 387-398. ISSN 0032-3861. IF: 3.586.
  • [6]
    FÜLÖPOVÁ, V. a M. SOURAL. Solid-Phase Synthesis of Heterocycles with -Haloketones as the Key Building Blocks. Synthesis-Stuttgart. 2016, 48(21), 3684. ISSN 0039-7881. IF: 2.650.
  • [5]
    SOURAL, M., J. HLAVÁČ, P. HRADIL a M. HAJDÚCH. Efficient Synthesis and Cytotoxic Activity of Some Symmetrical Disulfides Derived from the Quinolin-4(1H)-one Skeleton. European Journal of Organic Chemistry. 2009, -(23), 3867-3870. ISSN 1434-193X. IF: 3.016.
  • [4]
    DRÁBIKOVÁ, M., S. KRAJČOVIČOVÁ a M. SOURAL. Mitsunobu C-alkylation of beta-alkoxycarbonyl 2-nitrobenzenesulfones and its use for the rapid synthesis of novel benzothiazine derivatives. Tetrahedron. 2017, 73(44), 6296-6306. ISSN 0040-4020. IF: 2.651.
  • [3]
    RUČILOVÁ, V., P. KRÁLOVÁ a M. SOURAL. Synthesis of Disubstituted Pyrazino-Oxazine Derivatives with Controlled Stereochemistry. European Journal of Organic Chemistry. 2017, 47, 7034-7039. ISSN 1434-193X. IF: 2.834.
  • [2]
    HORÁK, R., L. KVAPIL, K. MOTYKA, L. SLANINOVÁ, M. GREPL, K. KOTISEK, M. URBASEK, P. HRADIL a M. SOURAL. Synthesis of 2-alkenyl-3-hydroxyquinolin-4(1H)-ones as promising antimicrobial and fluorescent agents. Tetrahedron. 2018, 74(74), 366-374. ISSN 0040-4020. IF: 2.651.
  • [1]
    RUČILOVÁ, V., M. MALOŇ a M. SOURAL. Use of Triethylsilane for Directed Enantioselective Reduction of Olefines: Synthesis of Pyrazino[2,1-c][1,4]oxazine-6,9-diones with Full Control of the Absolute Configuration. European Journal of Organic Chemistry. 2018, 4, 564-570. ISSN 1434-193X . IF: 2.834.

Book Chapters:

  • [1]
    RUČILOVÁ, V. a M. SOURAL. Solid-Phase Synthesis of Seven-Membered Heterocycles with Two Nitrogen Atoms. In: Topics in Heterocyclic Chemistry. x. x: Springer International Publishing, 2017. Kapitola 52, s. 23-63. ISBN: 978-3-642-15454-6.

Patents, Utility models & other IP's :

[3] 2-PHENYL-3-HYDROXYQUINOLIN-4(1H)-ONE-8-CARBOXAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND USE, Priority Appl. CZ PV 2010-476
  1. Patent: CZ 304 527, Granted: 7. 5. 2014, Ownership: Palacky University Olomouc, Inventors: Soural Miroslav, Hlaváč Jan, Hradil Pavel

Status: Terminated

[2] EFFICIENT METHOD OF BIOTINYLATION OF AMINO COMPOUNDS USING SOLID PHASE SYNTHESIS FOR AFFINITY CHROMATOGRAPHY NEEDS, Priority Appl. CZ PV 2010-229
  1. Patent: CZ 302 669, Granted: 13. 7. 2011, Ownership: Palacky University in Olomouc, Inventors: Soural MiroslavHlaváč JanHradil Pavel

Status: Terminated

[1] EFFICIENT METHOD OF BIOTINYLATION OF COMPOUNDS CONTAINING CARBOXYL GROUP USING SOLID PHASE SYNTHESIS FOR AFFINITY CHROMATOGRAPHY NEEDS, Priority Appl. CZ PV 2010-230
  1. Patent: CZ 302 510, Granted: 11. 5. 2011, Ownership: Palacky University Olomouc, Inventors:Soural Miroslav, Hlaváč Jan, Hradil Pavel

Status: Terminated


Doctoral students mentor:

[5] Patricia Trapani, Synthesis of benzothiadiazepines using solid-phase synthesis,
Ph.D. specialization: , status: Ongoing, from: 2018
[4] David Vanda, Synthesis of heterocyclic compounds as ligands of serotonine receptors and phosphodiesterases,
Ph.D. specialization: Medical chemistry, status: Ongoing, from: 2016
[3] Petra Králová, Developmet of methods of preparation of heterocyclic compounds with potential biological activity with use of solid-phase synthesis,
Ph.D. specialization: , status: Ongoing, from: 2016
[2] Soňa Krajčovičová, Solid-phase synthesis of heterocyclic compounds and study of their biological properties,
Ph.D. specialization: , status: Ongoing, from: 2015
[1] Veronika Ručilová, Development of Strategies for Solid-Phase Synthesis of Nitrogenous Heterocyclic Compounds Based on the 2- and 4-Nitrobenzenesulfonamide Chemistry,
Ph.D. specialization: , status: Graduated, from: 2011 to 2015


Master students mentor:

[6] Patricia Trapani, Synthesis of benzothiadiazepines using solid-phase synthesis,
status: Graduated, from: 2016 to 2018
[5] David Vanda, Syntéza derivátů purinu a deazapurinu a studium jejich biologických vlastností,
status: Graduated, from: 2011 to 2016
[4] Veronika Černínová, Preparation of new derivatives of the imidazopyridine with potential CNS activity,
status: Graduated, from: 2014 to 2016
[3] Miroslav Škrobánek, Development of methods for the preparation of imidazo [4 ', 5': 4,5] benzo [1,2-e] [1,4] diazepin-9 (3H) -one using solid-phase,
status: Graduated, from: 2013 to 2014
[2] Martina Drábiková, Synthesis of heterocyclic compound containing a sulfone or sulfonamide,
status: Ongoing, from: 2012
[1] Veronika Ručilová, Preparation of bisheterocyclic derivatives of 3-hydroxy-4(1H)-quinolinone-7-carboxamides,
status: Graduated, from: 2009 to 2011


Bachelor students mentor:

[3] Jiří Jančík, Preparation of new serotonin receptor ligands,
status: Ongoing, from: 2016
[2] Patricia Trapani, Synthesis of benzothiadiazepines using solid-phase synthesis,
status: Graduated, from: 2015 to 2016
[1] Veronika Ručilová, Solid-Phase synthesis of precursors of bisheterocyclic derivatives of 3-hydroxy-4(1H)-quinolinone.,
status: Graduated, from: 2006 to 2009