Laboratory of Experimental Medicine
The Laboratory of Experimental Medicine (LEM) was established in 1998 at the Department of Pediatrics, Faculty of Medicine and Dentistry, Palacky University and University Hospital in Olomouc. Later in 2010, the LEM became a moving force in building-up and establishment of the Institute of Molecular and Translational Medicine.
Our researchers are organized to research groups and perform molecular, cellular and integrative research at the highest international level and to train a new generation of successful scientists. We study biological processes that govern normal and pathological human bodily functions that are involved in disease pathogenesis. Albeit our research is disease agnostic, most of our expertise relates to cancer, inflammation, infection, rare diseases and neurodegeneration. Our spectrum of research ranges from basic and translational science, including research and development of small molecules, radiopharmaceutics, identification of new therapeutic targets, drug repurposing, first use of molecules in man (Phase I trials), biomarker identification and validation trials, development of in vitro diagnostics, through to real-world evidence studies using routinely collected data.Several of our research environments have been recognized as outstanding both at the national and European levels. We also strive to stimulate our young researchers with our enthusiasm for research and wish to increase their interest in both basic and applied sciences. We expose them to the most up-to-date science, cutting edge technologies and prepare them for lifelong learning in their future careers.
Research interests
Our research interests and domains include
- Research and development of small molecules and biologics for innovative therapies
- Imaging and tracing of human diseases, development of radiopharmaceutics
- Identification and validation diagnostic, prognostic and predictive biomarkers to advance early disease diagnostics and personalized medicine
- Better understanding disease complexity employing multidimensional -omic techniques (proteomics, genomics, transcriptomics, metabolomics, lipidomics, cellulomics, etc.)
- Advancing high-throughput biology and screening techniques in medical research
- Research on translational in vitro and in vivo models (e.g. organoids, patient-derived xenografts, induced pluripotent stem cells)
- Development of information technologies, including the artificial intelligence, and solutions to support data stewardship in biomedical domain
- Advancing nanotechnologies for treatment and detection of human disorders; Proof-of-concept preclinical and early clinical trials.
Selected publications
Toward best practice in cancer mutation detection with whole-genome and whole-exome sequencing.
Nature Biotechnology.
2021,
39(9),
1141-50,
ISSN: 1087-0156,
PMID: 34504346,
Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4.
Nature.
2017,
552(7684),
194-199,
ISSN: 0028-0836,
PMID: 29211715,
Books & book chapters
The Potential of Triterpenoids in the Treatment of Melanoma,
1.vyd,
Rijeka,
InTech,
2011,
7,
125-158,
Dedication: 305/09/1216,
ISBN: 978-953-307-293-7,
Open positions
| Project: | The role of tumor hypoxia in the emergence of acquired resistance to drugs aimed at microtubules |
|---|---|
| Supervisors: | Das Viswanath M.Sc., Ph.D. |
| Available: | 1 |
| Intended for: | Doctoral training |
| Summary: | 1 place in full-time study |
| Project: | Generation of 3D human neuronal cultures: application to modeling CNS diseases |
|---|---|
| Supervisors: | Das Viswanath M.Sc., Ph.D. |
| Available: | 1 |
| Intended for: | Master training |
| Summary: | - |
| Project: | Biochemical and cellular analysis of amyloid staining agents in models of tauopathies and synucleopathies |
|---|---|
| Supervisors: | Das Viswanath M.Sc., Ph.D. |
| Available: | 1 |
| Intended for: | Master training |
| Summary: | - |
| Project: | Investigating Effects of Aggregates of Intrinsically Disordered Proteins on Microglia: Implication for Neurodegenerative Diseases |
|---|---|
| Supervisors: | Das Viswanath M.Sc., Ph.D. |
| Available: | 1 |
| Intended for: | Master training |
| Summary: | - |
| Project: | Efficacy of Bruton Tyrosine Kinase Inhibitors Against Neuroinflammation in Neurodegenerative Diseases |
|---|---|
| Supervisors: | Das Viswanath M.Sc., Ph.D. |
| Available: | 1 |
| Intended for: | Master training |
| Summary: | - |
| Project: | Systems approaches to understanding aging and neurodegeneration |
|---|---|
| Supervisors: | Das Viswanath M.Sc., Ph.D. |
| Available: | 2 |
| Intended for: | Doctoral training |
| Project: | Role of axonal transport and pathology in neurodegeneration |
|---|---|
| Supervisors: | Das Viswanath M.Sc., Ph.D. |
| Available: | 2 |
| Intended for: | Doctoral training |
| Project: | Research and development of agents for cancer, neurodegenerative and infectious diseases |
|---|---|
| Supervisors: | De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D. |
| Available: | 5 |
| Intended for: | Doctoral training |
| Project: | Isolation and analysis of membrane lipid rafts using a non-targeted metabolomics and lipidomics approach |
|---|---|
| Supervisors: | Najdekr Lukáš Ph.D. |
| Available: | 1 |
| Intended for: | Doctoral training |
| Project: | Use of open-source software approaches for analysis of metabolomic and lipidomic clinical data |
|---|---|
| Supervisors: | Najdekr Lukáš Ph.D. |
| Available: | 1 |
| Intended for: | Doctoral training |
| Project: | Identification of proteomic biomarkers in proximal fluids and tissues |
|---|---|
| Supervisors: | Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D. |
| Available: | 2 |
| Intended for: | Doctoral training |
| Project: | Preclinical development of molecular imaging agents |
|---|---|
| Supervisors: | Petřík Miloš Ph.D. |
| Available: | 2 |
| Intended for: | Doctoral training |
| Project: | Plasmonic nanomaterials in cancer theranostics |
|---|---|
| Supervisors: | Ranc Václav Ph.D. |
| Available: | 2 |
| Intended for: | Doctoral training |
| Summary: | 2 places in full-time or part-time study |
| Project: | Ligand- and structure-based modeling of biologically active compounds |
|---|---|
| Supervisors: | Polishchuk Pavlo Ph.D., M.Sc. |
| Available: | 1 |
| Intended for: | Doctoral training |
| Project: | Biologically active molecules and their therapeutic combinations |
|---|---|
| Supervisors: | Hajdúch Marián M.D., Ph.D. |
| Available: | 2 |
| Intended for: | Doctoral training |
| Project: | Anticancer drugs targeting nucleic acid metabolism |
|---|---|
| Supervisors: | Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D. |
| Available: | 2 |
| Intended for: | Doctoral training |
| Project: | Identification of proteomic biomarkers in exhaled breath condensate patients with systemic or pulmonary disease |
|---|---|
| Supervisors: | Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D. |
| Available: | 2 |
| Intended for: | Doctoral training |
| Project: | Development of 3D pharmacophore signatures and their application in anticancer drug design |
|---|---|
| Supervisors: | Polishchuk Pavlo Ph.D., M.Sc. |
| Available: | 1 |
| Intended for: | Doctoral training |
| Project: | Genetic and epigenetic biomarkers in health and disease |
|---|---|
| Supervisors: | Slavkovský Rastislav Ph.D., Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D., Drábek Jiří Ph.D., Koudeláková Vladimíra Ph.D. |
| Available: | 5 |
| Intended for: | Doctoral training |
| Project: | Postdoctoral fellow/Researcher |
|---|---|
| Supervisors: | Polishchuk Pavlo Ph.D., M.Sc. |
| Available: | 1 |
| Intended for: | Postdoctoral training |
| Summary: |
The group of chemoinformatics and drug design at the Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University in Olomouc, Czech Republic (https://imtm.cz/laboratories/chemoinformatics-and-drug-design) seeks for a postdoctoral fellow with experience in chemoinformatics and programming. The primary objective of the group is development of new computational approaches and software tools in drug design and their application in medicinal chemistry projects on hit/lead identification/optimization and target identification. The successful candidate will be mainly involved into the project on de novo fragment-based drug design and optimization. He/she will implement new and improve existing tools and approaches, validate them retrospectively and apply those tools in ongoing medicinal chemistry projects conducting at our institution in close collaboration with medicinal chemists and biologists. The candidate can be involved in other research projects depending on his/her experience and skills. The formal requirements: PhD in chemistry, chemoinformatics, computer science or related fields or 3 years of experience in relevant fields experience with molecular docking/pharmacophore modeling/machine learning knowledge of RDKit good Python programming skills and experience in software development data analysis skills basic medicinal chemistry knowledge is a plus good publication record excellent writing and spoken English The position will be opened for 2-3 years with a possibility of extension. Informal inquiries as well as applications, including curriculum vitae and bibliography, cover letter describing candidate research interests and past accomplishments should be sent via email to pavlo.polishchuk@upol.cz. |
| Project: | Applicability domains in machine learning modeling |
|---|---|
| Supervisors: | Polishchuk Pavlo Ph.D., M.Sc. |
| Available: | 1 |
| Intended for: | Master training |
| Project: | Computationally guided optimization of compound properties |
|---|---|
| Supervisors: | Polishchuk Pavlo Ph.D., M.Sc. |
| Available: | 1 |
| Intended for: | Master training |
| Project: | Novel 3D pharmacophore representation for machine learning |
|---|---|
| Supervisors: | Polishchuk Pavlo Ph.D., M.Sc. |
| Available: | 1 |
| Intended for: | Master training |
| Project: | Fragment-based de novo design using pharmacophore models |
|---|---|
| Supervisors: | Polishchuk Pavlo Ph.D., M.Sc. |
| Available: | 1 |
| Intended for: | Master training |
| Project: | Radiolabelled peptides for cancer imaging |
|---|---|
| Supervisors: | Petřík Miloš Ph.D. |
| Available: | 1 |
| Intended for: | Master training |
| Project: | Radiolabelled siderophores for infection imaging |
|---|---|
| Supervisors: | Petřík Miloš Ph.D. |
| Available: | 1 |
| Intended for: | Master training |
| Project: | In vivo imaging of 68Ga labelled biomolecules |
|---|---|
| Supervisors: | Petřík Miloš Ph.D. |
| Available: | 1 |
| Intended for: | Bachelor training |
| Project: | Small animal imaging using microPET/SPECT/CT system in preclinical developement of potential drugs |
|---|---|
| Supervisors: | Nový Zbyněk Ph.D. |
| Available: | 1 |
| Intended for: | Bachelor training |
| Project: | Epigenetic biomarkers |
|---|---|
| Supervisors: | Drábek Jiří Ph.D. |
| Available: | 1 |
| Intended for: | Master training |
| Project: | Genetic biomarkers |
|---|---|
| Supervisors: | Drábek Jiří Ph.D. |
| Available: | 1 |
| Intended for: | Master training |
Laboratory head
Research groups
Senior research group
Senior research group
Senior research group
Senior research group
Junior research group
Senior research group
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