National Center for Medical Genomic

Medical genomics is a dynamically evolving scientific discipline that gathers and uses the genomic information of patients, their genetic relatives, and even the entire population to identify the genetic, genomic, and molecular basis of human health and disease. The aim of the NCMG is to create an infrastructure that allows rapid implementation of novel genomic technologies and enables their rational utilization in the characterization of the genetic underpinnings of human health and disease in the Czech Republic. As in other countries, the Czech Republic has a unique population with genetic variants that may be specific to this population. Understanding genetic variation in the Czech Republic and how it compares to other populations will be an important step in understanding how genetics affects the health of individuals in the Czech Republic. Together with continued technological advances in instrumentation, data analysis and data storage, the NCMG will build up a reference database of genetic variation of the Czech population that will be based on exome - and later - whole genome sequencing data. Medical genomics provides new methodologies for biomedical research, alters how we think about the causes of disease, and will change clinical practice in the near future. The NCMG infrastructure is therefore essential for the education and training of a new generation of scientists, computer scientists, bioinformaticians, statisticians, instrument operators, clinical geneticists, and clinicians.