Najdekr Lukáš Ph.D.
About me
My area of research was always within the grasp of the metabolomics field. After I studied biochemistry, I have been working at the University Hospital Olomouc and my PhD was focused on medical genetics – especially in the potential application of untargeted metabolomics tools in clinical practice as a diagnostic tool. During my first internship at the University of Barcelona (Barcelona, Spain) I have learnt how to work with cell cultures and various techniques in molecular biology. During my second internship in San Jose (CA, USA) at Thermo Fisher Scientific, I got advanced skills and training in Orbitrap-based mass spectrometers and software. I see the metabolomics great potential as a ‘universal’ diagnostic tool in personalised medicine. In my opinion, the first signs can already be seen e.g. as use of the iKnife or in the improvement in new-born screening across the world. As a part of a great team of the scientists of Phenome Centre Birmingham, I was able to participate in many projects which helped me to get deeper insights in cooperation between academia and commercial subjects (industry). Now I have returned to my alma mater to the Palacký University where I want to continue my research. In future, I would like to focus my efforts on the study of the oxidative stress on the metabolite level. I would like to transfer more of lipidomics research into clinical practice. In my opinion, lipidomics approach has a great diagnostic potential for clinicians and there are still many undiscovered research opportunities.
Journals
Master mentorship
Pokorná Natálie
Development and validation of LC/MS assay for analyses of fat-soluble vitamins
Bachelor mentorship
Machálková Markéta
Untargeted metabolomics of T-lymphoblastic leukemia cells affected by quinolinone derivative
Šťastná Veronika
Metabolomic analysis of mouse plasma using aminopropyl column and TripleQ-MS
Mádrová Lucie M.Sc
Analysis of lipids in blood stains for the diagnosis of inherited metabolic disorders
Open positions
| Project: | Application of untargeted lipidomics and metabolomics as a tool for generating hypotheses in personalized medicine |
|---|---|
| Supervisors: | Najdekr Lukáš Ph.D. |
| Available: | 1 |
| Intended for: | Doctoral training |
| Summary: | 1 place in full-time study |
| Project: | Applied lipidomics approach in the search for new clinical biomarkers and elucidation of the structure of unknown lipid species |
|---|---|
| Supervisors: | Najdekr Lukáš Ph.D. |
| Available: | 1 |
| Intended for: | Doctoral training |
| Summary: | 1 place in full-time study |
| Project: | Use of open-source software approaches for analysis of metabolomic and lipidomic clinical data |
|---|---|
| Supervisors: | Najdekr Lukáš Ph.D. |
| Available: | 1 |
| Intended for: | Doctoral training |
| Project: | Isolation and analysis of membrane lipid rafts using a non-targeted metabolomics and lipidomics approach |
|---|---|
| Supervisors: | Najdekr Lukáš Ph.D. |
| Available: | 1 |
| Intended for: | Doctoral training |
| Project: | Vitamin analysis in human plasma cohort by application of UHPLC-MS |
|---|---|
| Supervisors: | Najdekr Lukáš Ph.D. |
| Available: | 1 |
| Intended for: | Bachelor training |
| Summary: | Description: The main goal would be to learn basic analytical skills in the metabolomics laboratory. Starting with sample preparation (different types of extractions), followed by data acquisition on the LCMS analytical platform. The last step is a biological interpretation of measured data; in this case, the effects of vitamin deficiency or overdose on the human organism. |