Drábek Jiří Ph.D.

Drábek Jiří Ph.D.'s picture
Academic Title: Associate Professor
Phone: +420585632070
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My interests concern applied genetics. Application ranges from clinical diagnostics of inherited diseases and detection of somatic mutations in tumor to forensic identification and kinship testing. I insist on regulated quality and prefer Bayesian interpretation.


Publications (Impact Factor Journals):

  • [20]
    PEXA, T., J. KRAJSA, M. SANKOVA, P. VELEMINSKY, J. HAVRDA, T. KOTRLY a J. DRÁBEK. Identification of the skeletal remains of the Czech communist regime crime victim, priest Josef Toufar. Forensic Science International. 2018, -, -. ISSN 0379-0738. IF: 1.974. PMID: 30037506
  • [19]
    URBANOVSKÁ, I., M. HOUDOVÁ MEGOVÁ , Z. DWIGHT, O. KALITA, M. UVÍROVÁ, J. SIMOVA, L. TUČKOVÁ, P. BUZRLA, T. PALECEK, M. HAJDÚCH, J. DVORACKOVA a J. DRÁBEK. IDH Mutation Analysis in Glioma Patients by CADMA Compared with SNaPshot Assay and two Immunohistochemical Methods. Pathology & Oncology Research. 2018, -, -. ISSN 1219-4956. IF: 1.736. PMID: 29556922
  • [18]
    DRÁBEK, J., M. SMOLIKOVA, R. KALENDAR, F. LOPES PINTO, P. PAVLOUSEK, K. KLEPARNIK a I. FREBORT. Design and validation of an STR hexaplex assay for DNA profiling of grapevine cultivars. Electrophoresis. 2016, 37(23-24), 3059-3067. ISSN 0173-0835 . IF: 2.744. PMID: 27696463
  • [17]
    KISS, I., J. MLCOCHOVA, Z. BORTLICEK, A. POPRACH, J. DRÁBEK, P. VYCHYTILOVA-FALTEJSKOVA, M. SVOBODA, T. BUCHLER, S. BATKO, A. RYSKA, M. HAJDÚCH a O. SLABÝ. Efficacy and Toxicity of Panitumumab After Progression on Cetuximab and Predictive Value of MiR-31-5p in Metastatic Wild-type KRAS Colorectal Cancer Patients. Anticancer Research. 2016, 36(9), 7955-9. ISSN 0250-7005 . IF: 1.937. PMID: 27630355
  • [16]
    KLASKOVA, E., J. DRÁBEK, M. HOBZOVA, V. SMOLKA, M. SEDA, J. HYJÁNEK, R. SLAVKOVSKÝ, J. STRÁNSKÁ a M. PROCHAZKA. Significant phenotype variability of congenital central hypoventilation syndrome in a family with polyalanine expansion mutation of the PHOX2B gene. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic. 2016, 160(4), 495-498. ISSN 1213-8118 . IF: 0.894. PMID: 27485184
  • [15]
    KALITA, O., R. TROJANEC, M. HOUDOVÁ MEGOVÁ , M. HAJDÚCH, M. VAVERKA, L. HRABALEK, M. ZLEVOROVA, J. DRÁBEK, L. TUČKOVÁ a J. VRBKOVÁ. Glioblastoma multiforme in patients with history of extracranial cancer: Case series. Clinical Neurology and Neurosurgery. 2016, 144(-), 39-43. ISSN 0303-8467. IF: 1.381. PMID: 26971293
  • [14]
    DRÁBEK, J. Surmounting PCR challenge using Contradictory matrix from Theory of Inventive Problem Solving (TRIZ). SpringerPlus. 2016, 5(1), 1-6. ISSN 2193-1801 . IF: 1.130. PMID: 26835236
  • [13]
    STRÁNSKÁ, J., S. JANČÍK, R. SLAVKOVSKÝ, V. HOLINKOVÁ, M. RABČANOVÁ, P. VOJTA, M. HAJDÚCH a J. DRÁBEK. Whole genome amplification induced bias in the detection of KRAS-mutated cell populations during colorectal carcinoma tissue testing. Electrophoresis. 2015, 36(6), 937-40. ISSN 0173-0835. IF: 2.482. PMID: 25655305
  • [12]
    DRÁBEK, J. a G. CEREDA. Interpreting noninvasive prenatal paternity tests. Genetics in Medicine. 2014, 16(10), 793-794. ISSN 1098-3600. IF: 7.329. PMID: 25290259
  • [11]
    HOUDOVÁ MEGOVÁ , M., J. DRÁBEK, V. KOUDELÁKOVÁ, R. TROJANEC, O. KALITA a M. HAJDÚCH. Isocitrate dehydrogenase 1 and 2 mutations in gliomas. Journal of Neuroscience Research. 2014, 92(12), 1611-1620. ISSN 0360-4012. IF: 2.594. PMID: 25078896
  • [10]
    LUKÁŠ, J., J. DRÁBEK, B. DUDESEK, P. VAZAN, J. STRÁNSKÁ, S. JANČÍK, M. MACKOVA, M. SYRUCEK, D. LUKAS, J. DUSKOVA a P. DUNDR. Correlation among the BRAF Gene Mutation Status, Clinicopathological Features of Primary Tumour, and Lymph Node Metastasizing of Papillary Thyroid Carcinoma. Experimental and Clinical Endocrinology and Diabetes. 2014, 122(5), 268-272. ISSN 0947-7349. IF: 1.555. PMID: 24839220
  • [9]
    KALLIFATIDIS, B., J. BOROVICKA, J. STRÁNSKÁ, J. DRÁBEK a D. MILLS. Fluorescent Random Amplified Microsatellites (F-RAMS) analysis of mushrooms as a forensic investigative tool. Forensic Science International: Genetics. 2014, 9(-), 25-32. ISSN 1872-4973. IF: 4.604. PMID: 24528576
  • [8]
    KOUDELÁKOVÁ, V., M. MEGOVÁ, R. TROJANEC, J. DRÁBEK a M. HAJDÚCH. Non-small cell lung cancer - genetic predictors. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic. 2013, 157(2), 125-136. ISSN 1213-8118. IF: 1.661. PMID: 23733083
  • [7]
    LUKÁŠ, J., J. DRÁBEK, D. LUKAS a J. GATEK. The epidemiology of thyroid cancer in the Czech Republic in comparison with other countries. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic. 2013, 157(3), 266-275. ISSN 1213-8118. IF: 1.661. PMID: 23132514
  • [6]
    JANČÍK, S., J. DRÁBEK, J. BERKOVCOVÁ, Y. XU, M. STAŇKOVÁ, J. KLEIN, V. KOLEK, J. ŠKARDA, T. TICHÝ, I. GRYGÁRKOVÁ, D. RADZIOCH a M. HAJDÚCH. A comparison of Direct sequencing, Pyrosequencing, High resolution melting analysis, TheraScreen DxS, and the K-ras StripAssay for detecting KRAS mutations in non small cell lung carcinomas. Journal of Experimental & Clinical Cancer Research. 2012, 31(1), 79. ISSN 1756-9966. IF: 3.066. PMID: 22995035
  • [5]
    SMILEK, P., J. NEUWIRTHOVA, J. JARKOVSKÝ, L. DUŠEK, J. ROTTENBERG, R. KOSTŘICA, J. SROVNAL, M. HAJDÚCH, J. DRÁBEK a J. KLOZAR. Epidermal growth factor receptor (EGFR) expression and mutations in the EGFR signaling pathway in correlation with anti-EGFR therapy in head and neck squamous cell carcinomas. Neoplasma. 2012, 59(5), 508-515. ISSN 0028-2685. IF: 1.547. PMID: 22668015
  • [4]
    JANČÍK, S., J. DRÁBEK, D. RADZIOCH a M. HAJDÚCH. Clinical Relevance of KRAS in Human Cancers. Journal of Biomedicine and Biotechnology. 2010, -(Article Number: 150960), 1-13. ISSN 1110-7243. IF: 1.230. PMID: 20617134
  • [3]
    DRÁBEK, J., M. HAJDÚCH, L. GOJOVÁ, E. WEIGL a V. MIHÁL. Frequency of 657del(5) mutation of the NBS1 gene in the Czech population by polymerase chain reaction with sequence specific primers. Cancer Genetics and Cytogenetics. 2002, 138(2), 157-159. ISSN 0165-4608. IF: 1.529. PMID: 12505263
  • [2]
    DRÁBEK, J. Two Fagan nomograms for the (genetic) evidence in a judicial context. Australian Journal of Forensic Sciences. 2014, 46(3), 266-271. ISSN 0045-0618. IF: 0.583.
  • [1]
    HAJDÚCH, M., J. DRÁBEK, V. RACLAVSKÝ, V. KOTALA a T. MICHALEK. Diversity among wild type and vaccination strains of Trichophyton verrucosum investigated by random amplified polymorphic DNA analysis. Folia Biologica. 1999, 45(4), 151-155. ISSN 0015-5500. IF: 0.632.

Publications (Other Reviewed Journals):

  • [13]
    DRÁBEK, J. (Ne)reprodukovatelnost výsledků v biomedicíně. Postgraduální medicína. 2018, 20(2), 227-230. ISSN 1212-4184.
  • [12]
    RYSKA, A., O. HORKY, J. BERKOVCOVÁ, I. TICHA, M. KALINOVA, M. MATEJCKOVA, A. BODAY, J. DRÁBEK, P. MARTINEK, J. SIMOVA, K. SIEGLOVA a H. VOSMIKOVA. afiliace FN_Malignant Melanoma - from Classical Histology towards Moleculat Genetic Testing. Klinická onkologie. 2017, 30(3), 182-189. ISSN 0862-495X.
  • [11]
    HOUDOVÁ MEGOVÁ , M., J. DRÁBEK, Z. DWIGHT, R. TROJANEC, V. KOUDELÁKOVÁ, J. VRBKOVÁ, O. KALITA, S. MLČOCHOVÁ, M. RABČANOVÁ a M. HAJDÚCH. Isocitrate Dehydrogenase Mutations are Better Prognostic Marker than O6-methylguanine-DNA Methyltransferase Promoter Methylation in Glioblastomas - a Retrospective, Single-centre Molecular Genetics Study of Gliomas. Klinická onkologie. 2017, 30(5), 361-371. ISSN 0862-495X.
  • [10]
    DRÁBEK, J. Omyly při soudním procesu. Bulletin advokacie. 2017, x(x), x. ISSN 1875-1768.
  • [9]
    KADLČÍKOVÁ, D., K. FUSEK a J. DRÁBEK. High resolution melting of Short Tandem Repeats amplicons. Forensic Science International: Genetics Supplement Series. 2017, 6, e335-e336. ISSN 1875-1768.
  • [8]
    DRÁBEK, J. 40 Inventive Principles for Genetic Diagnostic Laboratories. The Triz Journal. 2015, x, x. ISSN x.
  • [7]
    KULTAN, J., V. KOLEK, L. FAJKOSOVA, M. HAJDÚCH, J. DRÁBEK, T. TICHÝ a R. TACHEZY. Recurrent respiratory papillomatosis successfully treated with gefitinib: a case study. American Journal of Medical Case Reports. 2015, 3(11), 352-358. ISSN 2374-2151.
  • [6]
    DRÁBEK, J. Activity level in the hierarchy of propositions in case of the People of the State of California v. Orenthal James Simpson analyzed using Bayesian network. Forensic Science International: Genetics Supplement Series. 2015, 5(-), e67-e68. ISSN 1875-1768 .
  • [5]
    ONDRYÁŠOVÁ, H., V. KOUDELÁKOVÁ, J. DRÁBEK, P. VANEK, R. SLAVKOVSKÝ a M. HAJDÚCH. Utilization of self-sampling kits for HPV testing in cervical cancer screening - pilot study. Česká gynekologie. 2015, 80(6), 436-443. ISSN 1210-7832.
  • [4]
    DRÁBEK, J. Odmitnuti zaveru znaleckeho posudku v anglickem pripadu R proti T. Trestněprávní revue. 2014, 2(13), 40-43. ISSN 1213-5313.
  • [3]
    NEUWIRTHOVA, J., P. SMILEK, J. JARKOVSKÝ, L. DUŠEK, J. ROTTENBERG, R. KOSTŘICA, J. SROVNAL, M. HAJDÚCH, J. DRÁBEK, J. KLOZAR a R. CERVENA. Sledování mutace KRAS při léčbě cetuximabem u spinocelulárních karcinomů hlavy a krku. Remedia. 2012, 22(3), 231-234. ISSN 0862-8947.
  • [2]
    DUBSKA, L., M. VYSKOCILOVA, R. NENUTIL, D. VALIK, D. KNOFLICKOVA, P. FABIAN, I. KOCAKOVA, R. DEMLOVA, M. BERANEK, M. DRASTIKOVA, H. VOSMIKOVA, A. BODAY, K.. HORKA, J. SIMOVA, J. DRÁBEK, J. EHRMANN, M. HAJDÚCH, M. MATEJCKOVA, R. SIMA, D. TVRDIK, C. POVYSIL a A. RYSKA. Vyšetření mutačního statutu genu KRAS jako součást algoritmu léčby metastatického kolorektálního karcinomu. Časopis lékařů českých. 2011, 150(6), 321-326. ISSN 0008-7335.
  • [1]
    DRÁBEK, J. a R. BRDICKA. Principy pro zachazeni s lidskym genetickym materialem a genotypizacni informaci. Časopis lékařů českých. 2010, 151(11), 507-513. ISSN 0008-7335.

Book Chapters:

  • [2]
    HAJDÚCH, M., J. DRÁBEK a R. TROJANEC. Význam biomarkerů pro indikaci cílené biologické léčby v onkologii. In: Biologická léčiva: Teoretické základy a klinická praxe. 1. vyd. Praha: Grada Publishing, 2012. Kapitola 2.8, s. 137-149. ISBN: 978-80-247-3727-0.
  • [1]
    DRÁBEK, J. Design primerů pro polymerázovou řetězovou reakci (PCR). In: Detekce nádorových biomarkerů v molekulárně biologické laboratoři. 1.vyd. Olomouc: Univerzita Palackeho v Olomouci, 2012. Kapitola 5, s. 45-56. ISBN: 978-80-244-3199-4.

Books:

  • [3]
    DRABEK, J., J. BERKOVCOVA, P. DŽUBAK, M. HAJDUCH, M. KHOYLOU, V. KOUDELAKOVA, J. SROVNAL, M. STAŇKOVA a R. TROJANEC. Detekce nádorových biomarkerů v molekulárně biologické laboratoři. 1. vyd. Olomouc: Univerzita Palackého v Olomouci, 2012. 144 s. ISBN: 978-80-244-3002-7.
  • [2]
    HAJDUCH, M., J. DRABEK a R. TROJANEC. Biologická léčiva: Teoretické základy a klinická praxe. 1. vyd. Praha: Grada Publishing, 2012. 219 s. ISBN: 978-80-247-3727-0.
  • [1]
    DRABEK, J. Interpretace DNA profilu pri urcovani otcovstvi a pribuznosti. 1. vyd. Brno: Tribun EU, s.r.o., 2011. 95 s. ISBN: 978-80-263-0066-3.

Doctoral students mentor:

[2] Lucie Kotková, Genetic and Epigenetic Biomarkers in cancer,
Ph.D. specialization: , status: Ongoing, from: 2017
[1] Sylwia Jančík, New strategies for genotyping of KRAs and BRAF onkomarkesrs in heterogeneous clinical tumors samples,
Ph.D. specialization: Pediatrics, status: Graduated, from: 2009 to 2015


Master students mentor:

[5] Kristýna Michalcová, Epigenetic resolution monozygotic twins,
status: Graduated, from: 2015 to 2017
[4] Lucie Kotková, Optimization of library preparation for NGS,
status: Graduated, from: 2015 to 2017
[3] Hana Crlíková, Stabilisation of PCR reagents for storing at room temperature,
status: Graduated, from: 2015 to 2016
[2] Eva Hrušková, Testing the temperature uniformity of the thermocyclers using melting temperature of the same amplicon,
status: Graduated, from: 2010 to 2015
[1] Gabriela Gabčová, Detection of predictive genetic oncomarkers of EGFR signalling pathway using sequencing technologies,
status: Graduated, from: 2010 to 2015


Bachelor students mentor:

[2] Dominika Kadlčíková, Melting curve at microsatellite amplicons,
status: Graduated, from: 2015 to 2017
[1] Karel Fusek, Snapback PCR,
status: Graduated, from: 2015 to 2017