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Holub Dušan Ph.D.
Academic title:
M.Sc.
E-mail:
dusan.holub@upol.cz
Phone:
+420 585632068, +420 585632069
Groups:
DOCTORAL STUDENT, IMTM, LEM, STAFF
Doctoral training
Development of a method for the sensitive and quantitative determination of hepcidin in human serum using LCMS
Hepcidin, a 25 amino acid peptide, plays an important role in iron homeostasis. As such, it has potential as an indicator of any iron-related condition, such as anemia. My research focuses on the measurement of hepcidin in biological fluids to improve our understanding of iron-related disorders. A possible result of such studies could be the development of hepcidin as a tool for diagnosis and clinical management of such disorders.
Specialization:
Oncology
Supervisor:
Džubák Petr M.D., Ph.D.
Status:
Graduated from 2009 to 2016.
Journals
Hepcidin levels in Diamond-Blackfan anemia reflect erythropoietic activity and transfusion dependency.
Haematologica.
2014,
99(7),
e118-121,
ISSN: 0390-6078,
PMID: 24727814,
Iron status in patients with pyruvate kinase deficiency: neonatal hyperferritinaemia associated with a novel frameshift deletion in the PKLR gene (p.Arg518fs), and low hepcidin to ferritin ratios.
British Journal of Haematology.
2014,
165(4),
556-563,
ISSN: 0007-1048,
PMID: 24533562,
A complete search of combinatorial peptide library greatly benefited from probabilistic incorporation of prior knowledge.
International Journal of Mass Spectrometry.
2022,
471,
116723,
ISSN: 1387-3806,
PDF.