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Džubák Petr M.D., Ph.D.

Journals

VELAVAPALLI, V., V. MADDIPATI, S. GURSKÁ, N. ANNADURAI, B. LIŠKOVÁ, N. KATARI, P. DŽUBÁK, M. HAJDÚCH, V. DAS, R. GUNDLA
Novel 5-Substituted Oxindole Derivatives as Bruton's Tyrosine Kinase Inhibitors: Design, Synthesis, Docking, Molecular Dynamics Simulation, and Biological Evaluation. ACS Omega. 2024, 7(9), 8067-8081, ISSN: 2470-1343, PMID: 38405484,
GUTIERREZ, J., H. RAMIREZ, E. FERNANDEZ-MOREIRA, M. ACOSTA, M. MIJARES, J. DE SANCTIS, S. GURSKÁ, P. DŽUBÁK, M. HAJDÚCH, L. LABRADOR-FAGÚNDEZ, B. STELLA, L. DIAZ-PEREZ, G. BENAIM, J. CHARRIS
Synthesis, Antimalarial, Antileishmanial, and Cytotoxicity Activities and Preliminary In Silico ADMET Studies of 2-(7-Chloroquinolin-4-ylamino)ethyl Benzoate Derivatives. Pharmaceuticals . 2023, 16(12), 1709, ISSN: 1424-8247, PMID: 38139835,
KORABOINA, C., V. MADDIPATI, N. ANNADURAI, S. GURSKÁ, P. DŽUBÁK, M. HAJDÚCH, V. DAS, R. GUNDLA
Synthesis and Biological Evaluation of Oxindole Sulfonamide Derivatives as Bruton's Tyrosine Kinase Inhibitors. ChemMedChem. 2023, ISSN: 1860-7179, PMID: 37916435,

Books & book chapters

Detection and quantification of cellular antigens using flow cytometry, 1.vyd., Olomouc, Palacky University, 2021, 28, 209-214, Dedication: LO1304, ISBN: 978-80-244-6049-9,
Laboratory Techniques in Cellular and Molecular Medicine, 1.vyd., Olomouc, Palacky University, 2021, 436 s, Dedication: LO1304, ISBN: 978-80-244-6049-9,
Hmotnostní spektrometrie, 1. vyd, korigovaný dotisk, Olomouc, Univerzita Palackého v Olomouci, 2021, 2.2, 34-42, ISBN: 978-80-244-3951-8,

Intellectual property

CARBONIC ANHYDRASE INHIBITORS AND METHOD OF THEIR PRODUCTION (Řezáčová)
  1. Published Application PV 2011-676 (2.5.2013)
  2. Published Application PCT/CZ2012/000106 under WO 2013/060307 (2.5.2013)
  3. Patent: EP 2771015; Granted: 16.3.2016; Ownership: Institute of Organic Chemistry and Biochemistry CAS, Institute of Molecular Genetics CAS, Institute of Inorganic Chemistry CAS, Palacky University Olomouc; Inventors: Brynda Jiří, Cígler Petr, Gruner Bohumír, Maloy Řezáčová Pavlína, Mader Pavel, Šícha Václav, Bakardijev Mario, Džubák PetrHajdúch Marián
  4. Patent: US 9,290,529; Granted: 22.3.2016; Ownership: Institute of Organic Chemistry and Biochemistry CAS, Institute of Molecular Genetics CAS, Institute of Inorganic Chemistry CAS, Palacky University Olomouc; Inventors: Brynda Jiří, Cígler Petr, Gruner Bohumír, Maloy Řezáčová Pavlína, Mader Pavel, Šícha Václav, Bakardijev Mario, Džubák PetrHajdúch Marián

Status: Terminated

BIOAVAILABLE DITHIOCARBAMATE-METAL COMPLEX NANOPARTICLES, METHOD OF PREPARATION AND USE THEREOF "DISULFIRAM I" (Škrott)
  1. Patent: EP 3459526. Granted: 24.2.2021. Ownership: Palacky University, Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák PetrZbořil Radek.
  2. Published Application PCT/EP2018/076098 under WO 2019/063601 (4.4.2019)
  3. Patent: AU 2018340510. Granted: 5.8.2021. Ownership: Palacký University Olomouc. Inventors: Škrott ZdeněkMistrík MartinHajdúch MariánBártek JiříDžubák PetrZbořil Radek.
  4. Patent: CA 3,076,855. Granted: 26.4.2022. Ownership: Palacký University Olomouc. Inventors: Škrott ZdeněkMistrík MartinHajdúch Marián, Bártek Jiří, Džubák PetrZbořil Radek.
  5. Patent: KR 10-2456683. Granted: 14.10.2022. Ownership: Palacký University Olomouc. Inventors: Škrott ZdeněkMistrík MartinHajdúch Marián, Bártek Jiří, Džubák PetrZbořil Radek.
  6. Patent: JP 2020-537873. Granted: 29.9.2022. Ownership: Palacký University Olomouc. Inventors: Škrott ZdeněkMistrík MartinHajdúch Marián, Bártek Jiří, Džubák PetrZbořil Radek.
  7. Patent: MX 396,552. Granted: 17.10.2022. Ownership: Palacký University Olomouc. Inventors: Škrott ZdeněkMistrík MartinHajdúch Marián, Bártek Jiří, Džubák PetrZbořil Radek.

Status: Available

DIOXOCYCLOBUTENYL HYDRAZONES AND THEIR ANTICANCER ACTIVITY (Kaplánek)
  1. Patent: CZ 305626; Granted: 2.12.2015; Ownership: Institute of Chemical Technology Prague, Palacky University Olomouc, Institute of Molecular Genetics CAS; Inventors: Havlík Martin, Kaplánek Robert, Dolenský Bohumil, Rak Jakub, Bříza Tomáš, Džubák PetrHajdúch MariánKonečný PetrŠtěpánková Jana, Králová Jarmila, Král Vladimír

Status: Terminated

Postdoctoral mentorship

Znojek Pawel Ph.D.

HCT/HCA assays development

Status: Ongoing from 2013 to 2015.

Doctoral mentorship

Ječmeňová Kateřina

Drug resistance mechanisms in cancer

Status: Ongoing from 2020.
Kotulová Jana Ph.D.

Identification of adenosine receptor modulators and their anticancer properties

Status: Graduated from 2014 to 2022.
Stanková Jarmila

Cytotoxic drugs molecular target identification by methods of cell biology and proteomics

Status: Ongoing from 2016.

Master mentorship

Ječmeňová Kateřina

Development and characterization of resistant cell lines to purine and pyrimidine cytotoxic drugs

Status: Graduated from 2018 to 2020.
Růžičková Eliška B.Sc.

Evaluation of biological activity of demethylation drugs

Status: Graduated from 2013 to 2014.
Pastorková Barbora B.Sc.

Identification of molecular targets of anticancer drugs by immuno-affinity purification

Status: Graduated from 2013 to 2014.

Bachelor mentorship

Lónová Kateřina

Development and basic characterization of the cell line resistant to the CDK inhibitors

Status: Graduated from 2015 to 2016.

Open positions

Project: Identification of molecular targets and mechanisms of drug resistance by cellular methods biology and proteomics
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 places in full-time study
Project: Utilization of the space of unprecedented covalent inhibitors
Supervisors: Dömling Alexander PhD., Džubák Petr M.D., Ph.D.
Available: 1
Intended for: Doctoral training
Summary: 1 place in full-time study
Project: Identification of molecular targets of antitumor drugs using methods of cell biology and proteomics
Supervisors: Džubák Petr M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 places in full-time study
Project: Identification of proteomic biomarkers in tears of patients with neurodegenerative diseases
Supervisors: Džubák Petr M.D., Ph.D.
Available: 1
Intended for: Doctoral training
Summary: 1 place in full-time study
Project: Genetic and epigenetic biomarkers of cancer diseases
Supervisors: Slavkovský Rastislav Ph.D., Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D., Drábek Jiří Ph.D.
Available: 3
Intended for: Doctoral training
Summary: 3 places in full-time or combined form of study
Project: Identification of proteomic biomarkers in exhaled air condensate in patients with systemic or pulmonary disease
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 places in full-time study
Project: Identification of proteomic biomarkers in tears of patients with brain cancer
Supervisors: Džubák Petr M.D., Ph.D.
Available: 1
Intended for: Doctoral training
Summary: 1 place in full-time study
Project: Antitumor drugs targeting nucleic acid metabolism
Supervisors: Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 places in full-time study
Project: Targeted approaches to covalent inhibitors
Supervisors: Dömling Alexander PhD., Džubák Petr M.D., Ph.D.
Available: 1
Intended for: Doctoral training
Summary: 1 place in full-time study
Project: Synthesis of kinase inhibitors and their phenotypic chemoproteomic evaluation
Supervisors: Dömling Alexander PhD., Džubák Petr M.D., Ph.D.
Available: 1
Intended for: Doctoral training
Summary: 1 place in full-time study
Project: Identification of proteomic biomarkers in exhaled breath condensate patients with systemic or pulmonary disease
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Project: Anticancer drugs targeting nucleic acid metabolism
Supervisors: Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Project: Genetic and epigenetic biomarkers in health and disease
Supervisors: Slavkovský Rastislav Ph.D., Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D., Drábek Jiří Ph.D., Koudeláková Vladimíra Ph.D.
Available: 5
Intended for: Doctoral training
Project: Research and development of agents for cancer, neurodegenerative and infectious diseases
Supervisors: De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
Available: 5
Intended for: Doctoral training
Project: Identification of proteomic biomarkers in proximal fluids and tissues
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Project: Omic approaches in reproductive medicine
Supervisors: Džubák Petr M.D., Ph.D., Oždian Tomáš Ph.D.
Available: 1
Intended for: Doctoral training
Summary: 1 place in full-time study