Das Viswanath M.Sc., Ph.D.

Journals

DAS, V., S. MODARRES MOUSAVI, N. ANNADURAI, S. SUKUR, F. MEHRNEJAD, M. MORADI, L. MALINA, M. KOLARIKOVA, V. RANC, I. FRYDRYCH, R. KOURIL, S. HOSSEINKHANI, M. HAJDÚCH, M. NIKKHAH
Hydrophobic residues in the α-synuclein NAC domain drive seed-competent fibril formation and are targeted by peptide inhibitors. Federation of European Biochemical Societies. 2025, ISSN: 1742-464X, PMID: 40819250,  PDF.
DAS, V., L. DIOMEDE, L. MALINA, M. MOSCONI, N. ANNADURAI
Intrinsic aggregation and propagation of unmodified tau peptides: R2R3 as a minimal model system. Biophysical Journal. 2025, ISSN: 0006-3495 , PMID: 40515399,
DEVIATOV, A., I. KOZLOV, V. DAS
Differentiation of SH-SY5Y Cells into Cortical Neuron-like Cells for Tauopathy Modeling and Seeding Assays. Molecular Neurobiology. 2025, ISSN: 0893-7648, PMID: 40467940,  PDF.

Books & book chapters

DAS, V.
Multiparametric analysis of spheroid integrity by brightfield high-content microscopy , 1.vyd., Olomouc, Palacky University, 2021, 24, 177-182, Dedication: LO1304, ISBN: 978-80-244-6049-9,
DAS, V.
Cell lines and cell culture conditions - 3D cultures , 1.vyd., Olomouc, Palacky University, 2021, 2, 15, Dedication: LO1304, ISBN: 978-80-244-6049-9,
ANNADURAI, N., V. DAS
A combination of kinetic fluorometric assay and microscopy for the screening of potential anti-tau aggregating agents, 1.vyd., Olomouc, Palacky University, 2021, 41, 317-324, Dedication: LO1304, ISBN: 978-80-244-6049-9,

Doctoral mentorship

Annadurai Narendran M.Sc., Ph.D.

Identification and Characterisation of Tau minimal regions as Potential Pharmacological Targets against Tau Spreading in Tauopathies

Status: Graduated from 2015 to 2023.
Kozlov Ihor

Role of axonal transport and pathology in neurodegeneration

Status: Ongoing from 2023.

Master mentorship

Bechná Eliška

3D spheroids cultures of tumor cell lines for drug discovery studies

Status: Ongoing from 2022.
Pavlíková Martina

Specific pharmacological modulators of tau aggregation and spreading for Alzheimer's disease preclinical studies.

Status: Graduated from 2022 to 2024.
Skoupilová Patricie

Examination of mutations in tau on the activity of small molecules against prion-like tau formation in tauopathies

Status: Ongoing from 2023.

Bachelor mentorship

Chudáčková Alica

Investigating the biochemical and structural alterations in tau mutants caused by VQIVYK-targeting tau inhibitors

Status: Ongoing from 2023.
Vrablíková Barbora

Cytotoxicity of microtubule-stabilizing drug laulimalide in hypoxic human colorectal and cervical cancer cells

Status: Graduated from 2018 to 2020.

Open positions

Project: The role of tumor hypoxia in the emergence of acquired resistance to drugs aimed at microtubules
Supervisors: Das Viswanath M.Sc., Ph.D.
Available: 1
Intended for: Doctoral training
Summary: 1 place in full-time study
Project: Research and development of agents for cancer, neurodegenerative and infectious diseases
Supervisors: De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
Available: 5
Intended for: Doctoral training
Project: Role of axonal transport and pathology in neurodegeneration
Supervisors: Das Viswanath M.Sc., Ph.D.
Available: 2
Intended for: Doctoral training
Project: Systems approaches to understanding aging and neurodegeneration
Supervisors: Das Viswanath M.Sc., Ph.D.
Available: 2
Intended for: Doctoral training
Project: Mitochondrial and microglial dysfunction in tauopathies: effects of pathogenic TAU strains
Supervisors: Das Viswanath M.Sc., Ph.D.
Available: 1
Intended for: Doctoral training
Summary: 1 full-time position
Project: Investigating Effects of Aggregates of Intrinsically Disordered Proteins on Microglia: Implication for Neurodegenerative Diseases
Supervisors: Das Viswanath M.Sc., Ph.D.
Available: 1
Intended for: Master training
Summary: -
Project: Biochemical and cellular analysis of amyloid staining agents in models of tauopathies and synucleopathies
Supervisors: Das Viswanath M.Sc., Ph.D.
Available: 1
Intended for: Master training
Summary: -
Project: Generation of 3D human neuronal cultures: application to modeling CNS diseases
Supervisors: Das Viswanath M.Sc., Ph.D.
Available: 1
Intended for: Master training
Summary: -
Project: Efficacy of Bruton Tyrosine Kinase Inhibitors Against Neuroinflammation in Neurodegenerative Diseases
Supervisors: Das Viswanath M.Sc., Ph.D.
Available: 1
Intended for: Master training
Summary: -