Medicinal chemistry and bioactive natural products
Laboratory of Medicinal and Organic Chemistry
Our research group is currently focused on natural triterpenoids and their semi-synthetic analogues and on the studies of their biological activities. Based on the activities, we have two main domains of research.
- Compounds with anti-cancer activity
- Compounds with neuroprotective activity
Current projects
- Modifications of the position C-30 in lupane triterpenoids
- Triterpenoids with condensed heterocycle to the main skeleton
- Fluorescently labelled triterpenoids and their visualization in the living environment
- Bioorthogonal click-reaction of selectively cytotoxic triterpenes
- Development of compounds selectively cytotoxic in resistant cancer cells
- Compounds labelled with deuterium and their visualization using Raman confocal microscopy
- Natural products with neuroprotective properties and elucitation of their mechanism of action
Journals
Substituted dienes prepared from betulinic acid - Synthesis, cytotoxicity, mechanism of action, and pharmacological parameters.
European Journal of Medicinal Chemistry.
2021,
224,
113706,
ISSN: 0223-5234,
PMID: 34311159,
Novel pentacyclic triterpenes exhibiting strong neuroprotective activity in SH-SY5Y cells in salsolinol- and glutamate-induced neurodegeneration models.
European Journal of Medicinal Chemistry.
2021,
213,
113168,
ISSN: 0223-5234,
PMID: 33508480,
Group leader
Group members
CHEMISTRY, IMTM, MEDCHEM, STAFF
CHEMISTRY, IMTM, MEDCHEM, STAFF
MEDCHEM, MASTER STUDENT, BACHELOR STUDENT
IMTM, LEM, STAFF, SUPERVISOR