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The Laboratory of Medicinal and Organic Chemistry was established at the newly founded Institute of Molecular and Translational Medicine of the Faculty of Medicine and Dentistry of Palacký University in Olomouc in 2010. 

The laboratory currently consists of two separate research groups. In general, we focus on the synthesis of new organic molecules, most of which are useful in biological and medical research. The main part of our research is modern organic synthesis in solution and on solid phase, parallel synthesis, synthesis on nano and macro scale, targeted synthesis. We focus on biologically active compounds, especially natural substances, components of living systems and their analogues, heterocyclic compounds and other molecules with possible applications in medicine. Other techniques pursued are fragment- and structure-based as well as computational drug discovery. Special attention is paid to chemical modification of molecules to optimize their pharmacological parameters, bioavailability or activity. An integral part of our research is the measurement and analysis of physical and spectral data of these compounds, on the basis of which their structure can be determined. In the field of medicinal chemistry, we mainly investigate the interactions of molecules with living organisms and their mechanism of action. For this purpose, we create labelled molecules and molecular probes, trying to visualize them in cells. Therefore, we also focus on various bioorthogonal reactions. We collaborate with scientific teams both within the Czech Republic and worldwide on many of our goals.

An integral part of our research is the training of young students and researchers who have the opportunity to work on state of the art equipment and regularly gain experience on internships abroad and present the results of their research at international conferences.

  • Studies of organic reactions, multicomponent reactions, catalyzed reactions, discovery of new reactions, stereoselective synthesis
  • Development of new molecules, automation of organic synthesis
  • Elucidation of the structures of new molecules
  • Development of small molecules as potential innovative therapeutics or theranostics – in close collaboration with the Laboratory of Experimental Medicine
  • Drug optimization, prodrug synthesis, biorthogonal reactions and synthesis of labelled molecules (e. g. fluorescent or non-radioactive isotopes or PET)
  • Natural compounds and their semisynthetic analogues – isoprenoids, nucleic acids components, saccharides etc.
  • Compounds with anti-cancer, anti-infective, neuroprotective, anti-inflammatory and other biological effects
  • Drug delivery systems
PATIL, P., Q. ZHENG, K. KURPIEWSKA, A. DÖMLING
The isocyanide SN2 reaction. Nature Communications. 2023, 14(1), 5807, ISSN: 2041-1723, PMID: 37726293,
WAZYNSKA, M., R. BUTERA, M. REQUESENS, A. PLAT, T. ZARGANES-TZITZIKAS, C. NEOCHORITIS, J. PLEWKA, L. SKALNIAK, J. KOCIK-KROL, B. MUSIELAK, K. MAGIERA-MULARZ, I. RODRIGUEZ, S. BLOK, M. DE BRYUN, H. NIJMAN, P. ELSINGA, T. HOLAK, A. DÖMLING
Design, Synthesis, and Biological Evaluation of 2-Hydroxy-4-phenylthiophene-3-carbonitrile as PD-L1 Antagonist and Its Comparison to Available Small Molecular PD-L1 Inhibitors. Journal of Medicinal Chemistry. 2023, 66(14), 9577-9591, ISSN: 0022-2623, PMID: 37450644,
HODOŇ, J., I. FRYDRYCH, Z. TRHLÍKOVÁ, J. POKORNÝ, L. BORKOVÁ, S. BENICKÁ, M. VLK, B. LIŠKOVÁ, A. KUBÍČKOVÁ, M. MEDVEDÍKOVÁ, M. PISÁR, J. ŠAREK, V. DAS, A. LIGASOVÁ, K. KOBERNA, P. DŽUBÁK, M. HAJDÚCH, M. URBAN
Triterpenoid pyrazines and pyridines - Synthesis, cytotoxicity, mechanism of action, preparation of prodrugs. European Journal of Medicinal Chemistry. 2022, 243, 114777, ISSN: 0223-5234, PMID: 36174412, DATA.
HODOŇ, J., I. FRYDRYCH, Z. TRHLÍKOVÁ, J. POKORNÝ, L. BORKOVÁ, S. BENICKÁ, M. VLK, B. LIŠKOVÁ, A. KUBÍČKOVÁ, M. MEDVEDÍKOVÁ, M. PISÁR, J. ŠAREK, V. DAS, A. LIGASOVÁ, K. KOBERNA, P. DŽUBÁK, M. HAJDÚCH, M. URBAN
Triterpenoid pyrazines and pyridines - Synthesis, cytotoxicity, mechanism of action, preparation of prodrugs. European Journal of Medicinal Chemistry. 2022, 243, 114777, ISSN: 0223-5234, PMID: 36174412, DATA.
POKORNÝ, J., D. OLEJNÍKOVÁ, I. FRYDRYCH, B. LIŠKOVÁ, S. GURSKÁ, S. BENICKÁ, J. ŠAREK, J. KOTULOVÁ, M. HAJDÚCH, P. DŽUBÁK, M. URBAN
Substituted dienes prepared from betulinic acid - Synthesis, cytotoxicity, mechanism of action, and pharmacological parameters. European Journal of Medicinal Chemistry. 2021, 224, 113706, ISSN: 0223-5234, PMID: 34311159,
GONZALES, G., J. HODOŇ, A. KAZAKOVA, C. D´ACUNTO, P. KANOVSKY, M. URBAN, M. STRNAD
Novel pentacyclic triterpenes exhibiting strong neuroprotective activity in SH-SY5Y cells in salsolinol- and glutamate-induced neurodegeneration models. European Journal of Medicinal Chemistry. 2021, 213, 113168, ISSN: 0223-5234, PMID: 33508480,
C-28 BIOTINYLATED TRITERPENES OF A LUPANINE TYPE AND THEIR USE (Urban)

Patent: CZ 307229; Granted: 28.2.2018; Ownership: Palacky University, Olomouc; Inventors: Urban MilanSoural Miroslav, Šarek Jan

​Status: Terminated 

C-28 BIOTINYLATED HETEROCYCLIC TRITERPENES OF A LUPANINE TYPE AND THEIR USE (Urban)

Patent: CZ 307 165; Granted: 3.1.2018; Ownership: Palacky University, Olomouc; Inventors: Urban MilanSoural Miroslav, Šarek Jan

​Status: Terminated 

C-3 BIOTINYLATED TRITERPENES OF A LUPANINE TYPE AND THEIR USE (Urban)

Patent: CZ 307227; Granted: 28.2.2018; Ownership: Palacky University, Olomouc; Inventors: Urban Milan, Soural Miroslav, Šarek Jan

​Status: Terminated

Vývoj nových léčiv, 1. vyd, Praha, Galén, 2015, 11, 469-472, ISBN: 978-80-7492-121-6,
URBAN, M., M. KVASNICA, N. DICKINSON, J. ŠAREK
Biologically Active Triterpenoids Usable As Prodrugs, 1. vyd, New York, USA, Nova Science Publishers, 2015, 2, 25-50, Dedication: CZ.1.05/2.1.00/01.0030, ISBN: 978-1-63463-656-8,
ŠAREK, J., M. KVASNICA, M. VLK, M. URBAN, P. DŽUBÁK, M. HAJDÚCH
The Potential of Triterpenoids in the Treatment of Melanoma, 1.vyd, Rijeka, InTech, 2011, 7, 125-158, Dedication: 305/09/1216, ISBN: 978-953-307-293-7,